there is evidence of focal areas of nerve in which electrical impulses are slowed or blocked (conduction block) which can be detected on electrophysiology tests.there is no difficulty speaking or swallowing.there are no UMN (upper motor neuron) signs such as brisk reflexes at the knees or ankles or spasticity in the limbs.has a purely motor disorder affecting individual nerves.The diagnosis of MMN is a clinical one that depends on demonstrating that the patient: Even if these antibodies do not cause the nerve damage, they may be an important marker for disease and facilitate diagnosis. These antibodies have been detected with newer assays in almost all of MMN patients. Antibodies normally protect individuals from viruses and bacteria, but may under certain circumstances bind to and facilitate an immune attack on the peripheral nerve. MMN is associated with increased levels of specific antibodies to GM1, a ganglioside or sugar-containing lipid found in peripheral nerve. However appropriate treatment that is FDA approved does limit progression and improves function. Unlike other forms of chronic nerve inflammation, it is thought to never remit. However, unlike CIDP, MMN is asymmetric and affects the right and left side of the body differently. MMN has many features similar to CIDP in that its onset is progressive over time, causing increased disability that reflects the greater number of nerve sites involved. The prevalence of this very rare disease is estimated to be 0.6 cases in every 100,000 people, which makes it even rarer that GBS, a spontaneously self-limiting disorder in which 1-2/100,000 cases occur each year in North America and Europe. The clinical course of MMN is chronically progressive without remission. Patients with MMN can have other symptoms, including twitching, or small random dimpling of the muscle under the skin which neurologists call fasciculations. There is essentially no numbness, tingling, or pain. The weakness associated with MMN can be recognized as fitting a specific nerve territory. Patients frequently develop weakness in their hand(s), resulting in dropping of objects or sometimes inability to turn a key in a lock. Typically, MMN is slowly progressive, resulting in asymmetrical weakness of a patient’s limbs. MMN (Multifocal Motor Neuropathy) is a rare disorder in which focal areas of multiple motor nerves are attacked by one’s own immune system.
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